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465 From a more novel perspective, the findings that intralesional oncolytic herpes virus treatment enhances anticancer immune responses in immunosuppressive tumor microenvironments provide a biological rationale for the use of this oncolytic modality in cancers that are otherwise unresponsive to immunotherapy

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Notably, AcM concentration also led to a decreased ability of the caecal microbiota to generate energy through functions such as glycolysis and to a reduction in the metabolism of ribosomal protein and nucleotides, together with a depletion of DNA homologous recombination, replication, and mismatch repair